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HLA-DR12
HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.
Serology
The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215
Alleles
There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific.
Disease associations
DR12 is associated with vulval lichen sclerosus, and undifferentiated spondyloarthritis.
DRB1*1201 is associated with iritis in juvenile arthritis, primary antiphospholipid syndrome, tiopronin intolerance in rheumatoid arthritis, adult chronic articular Still's disease
DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population, and narcolepsy in the Japanese population.
Extended linkage
DRB112:DQA10505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease
DRB11201:DRB301/03: colorectal cancer
Genetic Linkage
| Serotypes | DRA | DRB1 | DRB3 | Serotypes | DRB1 | DQA1 | DQB1 | Serotypes | HLA-A | HLA-C | HLA-B | DRB1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DR11(5)-DR52 | *0101 | *1201 | *0101 | |||||||||
| *0101 | *1202 | *0201 | ||||||||||
| *0101 | *1202 | *0202 | ||||||||||
| *0101 | *1202 | *0301 | ||||||||||
| DR12(5)-DQ7 (7.5, 3) | *1201 | *0505 | *0301 | |||||||||
| *1202 | *0505 | *0301 | ||||||||||
| DR12(5)-DQ7 (7.3, 3) | *1201 | *0303 | *0301 | |||||||||
| DR12(5)-DQ7 (7.4, 3) | *1201 | *0401 | *0301 | |||||||||
| DR12(5)-DQ7 (7.6, 3) | *1201 | *0601 | *0301 | |||||||||
| A31(19)-Cw10-B51(5)-DR12(5) | *3101 | *0304 | *5101 | *1202 | ||||||||
| A11-Cw9-B75(15)-DR12(5) | *1101 | *0303 | *1502 | *1202 | ||||||||
| A2-Cw10-B13-DR12(5) | *0201 | *0304 | *1301 | *1202 |
HLA-DR12 is genetically linked to DR52 and HLA-DQ7 serotypes.
References
References
- [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
- DR8 - 2%
- (2005). "The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus.". J Invest Dermatol.
- (2007). "Human Leukocyte Antigens in Undifferentiated Spondyloarthritis". Seminars in Arthritis and Rheumatism.
- (1994). "Class II alleles in juvenile arthritis in Czech children.". J Rheumatol.
- (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients.". Arthritis Rheum.
- (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin. Exp. Rheumatol..
- (2001). "Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease.". Rheumatology (Oxford).
- (2006). "HLa-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)". Southeast Asian J. Trop. Med. Public Health.
- (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population.". Tissue Antigens.
- (1992). "HLA genotyping of colorectal carcinoma in the Chinese population.". Hum Immunol.
- (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol..
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