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HLA-DR11

HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.

Serology

The table above describes the efficiency of serological typing of DR11 and DR5. Serotypes are unknown the following alleles: DRB1*1110 to *1157

Disease associations

By serotype

DR11 is associated with grape anaphylaxis, well-differentiated thyroid cancer, low antibody production in Hepatitis C.

By allele(s)

DRB1*11 is associated systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody

DRB1*1101 is associated Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus, mite sensitive asthma, cervical cancer risk (HPV?)

DRB1*1102: Tiopronin intolerance in rheumatoid arthritis

DRB1*1104: pauciarticular juvenile rheumatoid arthritis

By haplotype

DR11 is an identifier for the DR11-DQ7/DR7-DQ2 transhaplotype isoform of celiac disease. DR11-DQ7.5 is identified as a risk factor in rheumatic heart disease.

DRB11101:DQA10505:DQB1*0301 haplotype is associated with Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus, mite sensitive asthma

DRB11102:DQA10505:DQB1*0301 haplotype is associated with hepatitis B virus persistence

Genetic Linkage

SerotypesDRADRB1DRB3SerotypesDRB1DQA1DQB1SerotypesHLA-AHLA-CHLA-BDRB1
DR11(5)-DR52*0101*1101*02
*0101*1102*02
*0101*1103*02
*0101*1104*02
DR11(5)-DQ7 (7.5, 3)*1101*0505*0301
*1102*0505*0301
*1103*0505*0301
*1104*0505*0301
A2-Cw7-B18-DR11*0201*0701*1801*1104
A24(9)-Cw4-B35-DR11*2402*0401*3501*1101
A24(9)-Cw14(BL)-B51(5)-DR11*2402*1402*5101*1104

HLA-DR11 is genetically linked to HLA-DR52 and HLA-DQ7(3) serotypes. The frequency node for DR11 is in the Levant and Anatolia. This serotype more than others appears to have spread with neolithization of Western Europe. The closely linked DQ7.5 appears to be protective against juvenile diabetes, in which wheat consumption appears to be a risk factor.

References

References

  1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  2. (2005). "Grape anaphylaxis: a study of 11 adult onset cases.". Allergy Asthma Proc.
  3. (2005). "Well differentiated thyroid carcinoma is associated with human lymphocyte antigen D-related 11 in Eastern Hungarians: a case of changing circumstances.". Cancer.
  4. (2006). "HLA-DR11 and HLA-DR2 are negatively associated with autoantibody production in chronic hepatitis C.". Ann Rheum Dis.
  5. (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody.". Arthritis Rheum.
  6. (1997). "Neonatal lupus erythematosus: studies on HLA class II genes and autoantibody profiles in Japanese mothers.". Autoimmunity.
  7. (1999). "Immunogenetics of atopic asthma: association of DRB11101 DQA10501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population.". Clin Exp Allergy.
  8. (2002). "Human leukocyte antigen class II and cervical cancer risk: a population-based study.". J Infect Dis.
  9. (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis.". Clin Exp Rheumatol.
  10. (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol.
  11. (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population.". Tissue Antigens.
  12. (2007). "Association of HLA DRB1-DQA1-DQB1 haplotypes with rheumatic heart disease in Taiwan". International Journal of Cardiology.
  13. (1999). "Class II HLA alleles and hepatitis B virus persistence in African Americans.". J Infect Dis.
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