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general/hla-dr-haplotypes

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HLA-DR10

Serotype

Serotype

HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.

Serology

The serological reaction of DR10 is relatively good.

Disease associations

By serotype

DR10 serotype or cognate alleles are associated with: Lichen planus

By allele

DRB1*1001 is associated with ovarian cancer and invasive squamous cell cervical cancer (SCC)

Extended linkage

DRB11001:DQA101:DQB1*05 haplotype: Rheumatoid arthritis The primary involvement appears to be DR10.

Genetic Linkage

DRADRB1DQA1DQB1DRB1HLA-AHLA-BDRB1
Haplotypes*0101*1001
Haplotypes*0101*0501*1001
Haplotypes*0000*0000*1001

HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5.

References

References

  1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  2. (1994). "HLA antigens in Arabs with lichen planus.". Clinical and Experimental Dermatology.
  3. (2006). "HLA-class II haplotype associations with ovarian cancer.". Int J Cancer.
  4. (2002). "Human leukocyte antigen class II and cervical cancer risk: a population-based study.". J Infect Dis.
  5. (2001). "Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition.". Arthritis Rheum.
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