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HLA-DQ9

Field	Value
isoformgroup	HLA-DQ9
polymer_type	MHC Class II, DQ cell surface antigen
image	DQ_Illustration.PNG
image_source	Illustration of HLA-DQ with bound peptide.
isoformCount	2
subunit1	DQA1
subunit2	DQB1
isoform1	DQ α2β9
nick1	DQ9.2
allele1a
allele1b	*0303
isoform2	DQ α3β9
nick2	DQ9.3
allele2a
allele2b	*0303
rareIsoforms	0

HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 broad antigen. DQ9 is determined by the antibody recognition of β9 and this generally detects the gene product of DQB1*0303.

Serology

Alleles link-out to IMGT/HLA Databease at EBI

The serotyping efficiency of DQ9 is poor. The recognition of DQB10303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DQB1 subgroup recognizes DQB10303 as efficiently as DQ3. For this reason DQ9 serotyping is a poor method of typing for transplantation or disease association prediction or study.

DQB1*0303

(DQ9) is associated with nasal polyps, gestational diabetes, microscopic polyangiitis (Japanese). Primary linkage is with DRB10901-DQB10303

Haplotypes and disease

DQ9.2

DQA10201:DQB10303 is associated with type I psoriasis (vulgaris),

DQ9.3

DQA10302:DQB10303 maybe associated with juvenile diabetes in the orient. (Chinese) Primary linkage of vitiligo is with DQA103-DQB10303.

References

[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
(2007). "Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps". Ann. Otol. Rhinol. Laryngol..
(2004). "Different HLA-DR-DQ and MHC class I chain-related gene A (MICA) genotypes in autoimmune and nonautoimmune gestational diabetes in a Swedish population". Hum. Immunol..
(2006). "Association of HLA-DRB10901-DQB10303 haplotype with microscopic polyangiitis in Japanese". Genes Immun..
(1993). "Oligonucleotide typing reveals association of type I psoriasis with the HLA-DRB10701/2, -DQA10201, -DQB1*0303 extended haplotype". J. Invest. Dermatol..
(2004). "HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han". Int. J. Dermatol..
(1994). "Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay". Diabetes Res. Clin. Pract..
(1992). "Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus". J. Clin. Endocrinol. Metab..
(2006). "MHC haplotypic association in Chinese Han patients with vitiligo". Journal of the European Academy of Dermatology and Venereology.

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hla-dq-haplotypes human-mhc-mediated-diseases

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