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HLA-B81

Human leukocyte antigen serotype

HLA-B81
Summary

Human leukocyte antigen serotype

HLA-B81 (B81) is an HLA–B serotype. The serotype identifies the HLA-B8101 and B8102 (very rare) gene products. B81 is more common in Subsaharan Africa. While there is a B81 serotype, serotyping of B81 is poor when simultaneously tested with anti-B7 or B48 antibodies. (For terminology help see: HLA-serotype tutorial)

Serotype

*8101876657

The serotype recognition of B*8101 is poor and is best identified by genetic techniques such as SSP-PCR and gene sequencing.

Allele frequencies

South Korea0.1
Regions of Africa with Higher B81 frequencies(Red-Orange)

HLA-B81 corresponds to a single allele B*8101. There are no characterized haplotypes of this allele that span multiple regions, though rare haplotypes certainly exist. The frequency in Kenya, Zimbabwe and Cameroon suggest that B81 probably expanded from core groups of Africans in Tanzania, Zambia or the Congo but with a limited spread due to its initial low frequency.

References

References

  1. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens.
  2. (1995). "Nucleotide sequence analysis of HLA-B1523 and B8101. Dominant alpha-helical motifs produce complex serologic recognition patterns for the HLA-B"DT" and HLA-B"NM5" antigens". Hum. Immunol..
  3. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  4. (2003). "New allele frequency database". Tissue Antigens.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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