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HLA-B58

Human leukocyte antigen serotype

Summary

Human leukocyte antigen serotype

Locuschr.6 6p21.31

HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57. The serotype identifies the more common HLA-B58 gene products. (For terminology help see: HLA-serotype tutorial) B5801 is associated with allopurinol induced inflammatory necrotic skin disease.

Serotype

5802723837

Allele distribution

Tunisia1.0

Disease

HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome. Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN). The association with allopurinol sensitivity in SJS/TEN was extremely strong in Asia, and somewhat less associated in Europeans.

References

References

  1. (1985). "The complete primary structure of HLA-Bw58". J. Biol. Chem..
  2. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens.
  3. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  4. (2003). "New allele frequency database". Tissue Antigens.
  5. (August 2007). "Human leukocyte antigens and drug hypersensitivity". Curr Opin Allergy Clin Immunol.
  6. (2009). "Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population". Pharmacogenet Genomics.
  7. Hung SI. (March 2005). "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol". Proc. Natl. Acad. Sci. U.S.A..
  8. Lonjou C. (February 2008). "A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs". Pharmacogenet. Genomics.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

hla-b-alleles drug-sensitivity-genes
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