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HLA-B53

Human leukocyte antigen serotype

Summary

Human leukocyte antigen serotype

HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products. The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion. This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. (For terminology help see: HLA-serotype tutorial)

Serotype

5302	80	20	5

B*5301 allele frequencies

	Mongolia Khalha	1.0

Haplotype frequencies

	Caucasian American	0.2

Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in African Americans.

References

(2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens.
(1991). "Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35". Hum. Immunol..
[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
(2003). "New allele frequency database". Tissue Antigens.
(2007). "High-resolution HLA alleles and haplotypes in the United States population". Hum. Immunol..

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

hla-b-alleles

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