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HLA-B52

Human leukocyte antigen serotype

Summary

Human leukocyte antigen serotype

Locuschr.6 6p21.31

HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.

B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B5101. There are a number of alleles within the B*52 allele group.

Serotype

Alleles link-out to IMGT/HLA Databease at EBI
Italy Bergamo0.6

Alleles

There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.

Disease

In ulcerative colitis

HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan.{{cite journal

In Takayasu's arteritis

Takayasu's arteritis appears to have an independent link to B52 associated disease. The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.

References

References

  1. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens.
  2. (January 2003). "Cloning and sequencing full-length HLA-B and -C genes". Tissue Antigens.
  3. (January 1989). "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain". J. Immunol..
  4. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  5. (2003). "New allele frequency database". Tissue Antigens.
  6. (February 1993). "Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis". Hum. Immunol..
  7. Sato, R. (December 1994). "Takayasu's disease associated with ulcerative colitis". [[Intern. Med.]].
  8. (August 1996). "Comprehensive analysis of HLA genes in Takayasu arteritis in Japan". Int. J. Cardiol..
  9. (August 1993). "DNA typing of HLA-B gene in Takayasu's arteritis". Tissue Antigens.
  10. (October 1998). "Association of clinical manifestations with HLA-B alleles in Takayasu arteritis". Int. J. Cardiol..
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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