HLA-B51

Serotype

Alleles

There are 71 alleles, 57 amino acid sequence variants in B51 of which 4 are nulls. Of these only 9 are frequent enough to have been reliably serotyped. B*5101 is the most common, but others have a large regional abundance.

Disease associations

By serotype

Bw51 was associated with Behçet's disease, in endemic (versus epidemic) mucocutaneous lymph node syndrome, susceptibility to the virus that causes German measles infection.

In Behçet's disease

Behçet's disease is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body. Several alleles of B51 (B5101, B5108, B5105, and B5104) are found in disease, and linkage to markers, D6S285, in the HLA locus was strong (P

However, B51 tends not to be found in ABD when a certain SUMO4 gene variant is involved, and symptoms appear to be milder when HLA-B27 is present.

References

References

1. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens.
2. (January 2003). "Cloning and sequencing full-length HLA-B and -C genes". Tissue Antigens.
3. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
4. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens.
5. (September 1982). "Close association of HLA-Bw51 with Behçet's disease". Arch. Ophthalmol..
6. (August 1982). "HLA Bw51 is increased in mucocutaneous lymph node syndrome in Israeli patients". Tissue Antigens.
7. (1981). "Host factors and susceptibility to rubella virus infection: the association of HLA antigens". J. Med. Virol..
8. (2008). "The genetics of Adamantiades-Behcet's disease". Semin Ophthalmol.
9. (June 2005). "Whole-genome screening for susceptibility genes in multicase families with Behçet's disease". Arthritis Rheum..
10. (June 2008). "Ocular involvement is associated with HLA-B51 in Adamantiades-Behçet's disease". Eye.
11. (2007). "Behçet's disease in Tunisia. Demographic, clinical and genetic aspects in 260 patients". Clin. Exp. Rheumatol..
12. (2007). "Association of Major Histocompatibility Complex Class I Chain-Related Gene A and HLA-B Alleles with Behçet's Disease in Turkey". Jpn. J. Ophthalmol..
13. (February 2007). "Haplotype association of IL-8 gene with Behcet's disease". Tissue Antigens.
14. (March 2007). "Immunopathogenesis of Behçet's disease with special emphasize on the possible role of antigen presenting cells". Rheumatol. Int..
15. (February 2006). "The alteration of sister chromatid exchange frequencies in Behçet's disease with and without HLA-B51". J Eur Acad Dermatol Venereol.
16. (July 2008). "SUMO4 gene polymorphisms in Chinese Han patients with Behcet's disease". Clin. Immunol..
17. (October 2007). "Human leukocyte antigen B27 and B51 double-positive Behçet uveitis". Arch. Ophthalmol..