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HLA-A36

Human leukocyte antigen serotype

Summary

Human leukocyte antigen serotype

Distribution

	Berber (Morocco)	0.0

A36 is largely limited to Africa. Outside Africa, more than half of the populations have no A36 and the majority that do, have only trace levels. The exception is in Central/East Central Asia. This appears not to be coincidental. HLA DR3-DQ2 linkage and frequency indicates a strong possibility of a recent migration from either North or West Africa in which the DR3-DQ2 (notably DRB10302) and A33-B*58 haplotypes were carried into and redistributed from Central Asia into the surrounding populations.

References

(1992). "HLA 1991: proceedings of the eleventh International Histocompatibility Workshop and Conference, held in Yokohama, Japan, 6–13 November 1991". Oxford University Press.
(2001). "HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations". Tissue Antigens.
(2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A2612-B4407 haplotype". Tissue Antigens.
(2001). "Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations". Hum. Immunol..

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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