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HLA-A23

Human leukocyte antigen serotype

Summary

Human leukocyte antigen serotype

Field	Value
isoformgroup	HLA-A23
polymer_type	MHC Class I, A cell surface antigen
image	Illustration_HLA-A.png
protein_type	transmembrane receptor/ligand
structure	αβ heterodimer
subunit_genes	HLA-A*2301, β2-microglobulin
linkout	HAwA
alias	HL-A9
isoformCount	1
subunit1	allele
nick1	A23
allele1a	2301

HLA-A23 (A23) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α23 subset of HLA-A α-chains. For A23, the alpha, "A", chain are encoded by the HLA-A allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*2301. A23 and A are almost synonymous in meaning. A23 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A24.

A23 is common in Africa and regions of the Middle East, Mediterranean, and India than Europe, East Asia or the Americas.

Serotype

Allele

Haplotypes

A23-B7 is found in N.Afr. and S.Afr non-caucasians.

A23-B44 is found in Albania, Zimbabwe, Morocco, Spain and Danes.

A23-B58 is found in the !kung and Zaire.

Associated diseases

A23:Cw07 is associated with higher viral load in HIV

References

(February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens.
(2002). "Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1.". J Virol.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

hla-a-alleles

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