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HLA-A10

Human leukocyte antigen serotype

Summary

Human leukocyte antigen serotype

HLA-A10 is a broad antigen HLA-A serotype. The ancestral A10 type is believed to be A2601, which via gene conversion with other HLA-A alleles produced A2501, A3401, A4301 and A6601. A10 serotypes in general show a pattern of more recent expansion. A34 is an excellent example, appearing to have expanded from the middle east, with linkage disequilibrium with B alleles into Austronesia, South Pacific, Philippines and as far north as Taiwan (where it is found in the Taiwan Ami and Yami tribal groups but rare in ethnic Chinese nor in Hong Kong Chinese). A66 appears to have expanded from North Africa into the Middle East or Europe and A26 appears to have expanded Black Sea and, after the initial settlement from the southern West Pacific Rim peoples, into Japan . Whether this is a secondary migration from Africa or a re-expansion from within Eurasia is unclear.

References

References

  1. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens.
  2. (1999). "HLA class I allele distributions in six Pacific/Asian populations: evidence of selection at the HLA-A locus". Tissue Antigens.
  3. (2004). "HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia". Tissue Antigens.
  4. (2002). "The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos". Tissue Antigens.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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