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Hippuristanol

Hippuristanol is a small molecule found in the coral Isis hippuris which was discovered by Jerry Pelletier and others of McGill University in Montreal, Quebec, Canada. It appears to have anti-viral activity and may hold promise as a cancer therapy. Binds to and inhibits the eukaryotic translation initiation factor protein eIF4A.

References

References

  1. (2006). "Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A". Nature Chemical Biology.
  2. [http://www.sciencebase.com/science-blog/coral-kills-virus.html Killer Coral Compound], sciencebase 12 March 2006
  3. [http://www.sciam.com/article.cfm?articleID=000A9304-02D9-1412-82D983414B7F0000 Compound from Coral Could Combat Cancer] ''Scientific American'' March 13, 2006
  4. (2016-01-02). "Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A". Informa UK Limited.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

sterols spiro-compounds hexacyclic-compounds
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