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Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Class of enzymes

Class of enzymes

FieldValue
NameHexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
EC_number2.5.1.83

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (, HexPS, hexaprenyl pyrophosphate synthetase, hexaprenyl diphosphate synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units). This enzyme catalyses the following chemical reaction

: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate \rightleftharpoons 3 diphosphate + all-trans-hexaprenyl diphosphate

The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.

References

References

  1. (December 1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components". The Journal of Biological Chemistry.
  2. (March 1998). "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase". Journal of Bacteriology.
  3. (August 2001). "Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases". Bioorganic & Medicinal Chemistry Letters.
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ec-2.5.1
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