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general/beta-carbolines

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Harmalol

Harmalol is a bioactive β-carboline and a member of the harmala alkaloids.

Pharmacology

Pharmacokinetics

The elimination half-life of harmalol has been reported to be 30 to 49hours.

Society and culture

Australia

Harmala alkaloids are considered Schedule 9 prohibited substances under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.

Canada

Harmalol is a controlled substance in Canada.

References

References

  1. Thieme Chemistry (Hrsg.): RÖMPP Online – Version 3.37. Georg Thieme Verlag KG, Stuttgart, 27. September 2013.
  2. (2014). "Binding of alkaloid harmalol to DNA: photophysical and calorimetric approach.". J Photochem Photobiol B.
  3. (2012). "Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms.". Food Chem Toxicol.
  4. (October 2020). "Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact". Pharmaceuticals (Basel).
  5. Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534
  6. "Controlled Drugs and Substances Act".
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beta-carbolines n-monoalkyltryptamines tryptamine-alkaloids
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