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Haplogroup Q-M346

Human Y-chromosome DNA haplogroup

Field	Value
name	Q-M346
origin-date	24,100-27,900 BP
origin-place	Eurasia
ancestor	Q-MEH2
descendants	Q-L54, Q-M323
mutations	L56, L57, M346

| origin-date = 24,100-27,900 BP | origin-place = Eurasia Haplogroup Q-M346 is a subclade of Y-DNA Haplogroup Q. Haplogroup Q-M346 is defined by the presence of the M346 Single Nucleotide Polymorphism (SNP).

Origin and distribution

Q-M346 was discovered in Central Asia and announced in Sengupta 2006. A latter paper suggested that its ancestral state was isolated to India, but this has since been refuted by its presence in West Asia, Europe and the Americas.

Asia

Q-M346 has a wide distribution across much of Asia.

Population				Paper		N		Percentage		SNP Tested
Altaians (Russia - Siberia)
Khakas people	Khakassians (Russia - Siberia)
Todjins (Russia - Siberia)
Tuvinians (Russia - Siberia)
Soyot/Sojots (Russia - Siberia)
Kalmyks
Halba
Makrani
Pathan
Brahmin (Uttar Pradesh, India)
Vellalar (South India)
Pakistan
Kazakhs (Southwest Altai)
Chelkan (Russia - Siberia)
Tubalar Russia - Siberia]

The Americas

In the Americas, the founding paternal lineages include those who are Q-M346 but do not belong to the Q-M3 lineage.

Population				Paper		N		Percentage		SNP Tested
Enxet
Ayoreo
Wichi
Mocovi
Mapuche
Salta
Cordoba
Huilliche
La Paz
Tarija

Associated SNPs

Q-M346 is marked by the presence of the M346 SNP. Since the discovery of M346 several additional SNPs have been found to also be associated with Q-M346. These SNP's include: L56 and L57. These SNPs appear to be "parallel" to M346.{{cite web |archive-url = https://web.archive.org/web/20150815071342/http://ytree.ftdna.com/index.php?name=Draft |archive-date = 2015-08-15

Subgroups

This is Thomas Krahn's—of the Genomic Research Center—draft tree, Proposed Tree, for haplogroup Q-M346. The first three levels of subclades are shown. Additional detail is provided on the linked branch article pages.

Q-MEH2 MEH2, L472, L528
- Q-M346 M346, L56, L57, L474, L892, L942
  - Q-M323 M323
  - Q-L717 L717, L718
  - Q-L940 L940
    - Q-L527 L527, L529, L639
    - Q-L933 L933, L938, L941
  - Q-L53 L53, L55, L213, L331, L475, L476
    - Q-L54 L54

References

(2006). "Polarity and Temporality of High-Resolution Y-Chromosome Distributions in India Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence of Central Asian Pastoralists". The American Journal of Human Genetics.
(2007). "A novel subgroup Q5 of human Y-chromosomal haplogroup Q in India". BMC Evolutionary Biology.
(2009). "Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions". BMC Genetics.
(2009). "Brief communication: Restricted geographic distribution for Y-Q* paragroup in South America". American Journal of Physical Anthropology.
(2011). "Ancient links between Siberians and Native Americans revealed by subtyping the Y chromosome haplogroup Q1a". Journal of Human Genetics.
K. Abu-Amero, Khaled. (2009). "Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions". BMC Genetics.
(2011). "Y-Chromosome Variation in Altaian Kazakhs Reveals a Common Paternal Gene Pool for Kazakhs and the Influence of Mongolian Expansions". PLOS ONE.
(2012). "Mitochondrial DNA and Y Chromosome Variation Provides Evidence for a Recent Common Ancestry between Native Americans and Indigenous Altaians". The American Journal of Human Genetics.
(2011). "Distribution of Y-chromosome q lineages in native americans". American Journal of Human Biology.

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