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GPR128

Protein-coding gene in the species Homo sapiens

Protein-coding gene in the species Homo sapiens

G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene. GPR128 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Tissue distribution

GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.

Function

Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.

Clinical significance

A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms. Notably, the fused gene was also detected in few healthy individuals.

References

References

  1. "Entrez Gene: GPR128 G protein-coupled receptor 128".
  2. (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters.
  3. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews.
  4. Stacey M, Yona S. (2011). "Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology)". Springer.
  5. (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling.
  6. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal.
  7. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews.
  8. (January 2014). "Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency". World Journal of Gastroenterology.
  9. (January 2010). "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals". Haematologica.
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