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GPR114

Protein-coding gene in the species Homo sapiens

Protein-coding gene in the species Homo sapiens

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene. GPR114 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Tissue distribution

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.

Signaling

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gαs protein.

References

References

  1. "Entrez Gene: GPR114 G protein-coupled receptor 114".
  2. (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters.
  3. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews.
  4. Stacey M, Yona S. (2011). "Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology)". Springer.
  5. (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling.
  6. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal.
  7. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews.
  8. (April 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters.
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