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Glycosylphosphatidylinositol phospholipase D

FieldValue
NameGlycosylphosphatidylinositol phospholipase D
EC_number3.1.4.50
CAS_number113756-14-2

Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase. This enzyme catalyses the following chemical reaction

: 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myoinositol + H2O \rightleftharpoons 6-(α-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate

This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.

References

References

  1. (February 1988). "A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma". Proceedings of the National Academy of Sciences of the United States of America.
  2. (December 1986). "Conversion of human placental alkaline phosphatase from a high ''M''r form to a low ''M''r form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases". The Biochemical Journal.
  3. (November 1994). "Structural features of GPI-specific phospholipase D revealed by proteolytic fragmentation and Ca2+ binding studies". The Journal of Biological Chemistry.
  4. (March 2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". Journal of Lipid Research.
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