Glycosphingolipid

Classification

In general, glycosphingolipids can be categorized into two groups: neutral glycosphingolipids (also called glycosphingolipids) and negatively charged glycosphingolipids. The latter can be distinguished again by means of the charge carrier: gangliosides, which have sialic acids; and sulfatides, which have a sulfate group. The structural similarity of most glycolipids is the so-called lactosylceramide, that is, a lactose disaccharide that is glycosidically bound to a ceramide. Larger structures are subdivided into different groups by the sequence and configuration of the sugars, the four most common being globo-, lacto-, neoLacto- and gangliose.

Glycosphingolipids include:

• Cerebrosides
• Gangliosides
• Globosides
• Isoglobotriosylceramide

Occurrence and function

Gangliosides are mainly found in the cell membranes of the central nervous system, where their carbohydrate group is responsible for the interaction between individual cells and for signaling. However, gangliosides are also found in other cells. Sialic acids are, for example, part of the so-called sialyl-Lewis-x structure, a tetrasaccharide, which is important for various signal transduction processes. Neutral glycosphingolipids are also important, for example as blood type antigens.

Inheritable enzyme defects can lead to disruption in degradation and therefore to accumulation of glycolipids in various organs. In the case of cerebrirosis, this affects the cerebrosides (examples are Gaucher's disease and Krabbe's disease); in the case of gangliosides, it affects the gangliosidoses (e.g. Tay–Sachs disease).

References

References

1. (2010). "Sphingolipids as signaling and regulatory molecules". Springer.