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Glycoside hydrolase family 59

FieldValue
SymbolGlyco_hydro_59
NameGlycosyl hydrolase family 59
PfamPF02057
Pfam_clanCL0058
InterProIPR001286
OPM family117
OPM protein3zr5
CAZyGH59

In molecular biology, glycoside hydrolase family 59 is a family of glycoside hydrolases.

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of 100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

Glycoside hydrolase family 59 CAZY GH_59 comprises enzymes with only one known activity; galactocerebrosidase (). Globoid cell leukodystrophy (Krabbe disease) is a severe, autosomal recessive disorder that results from deficiency of galactocerebrosidase (GALC) activity. GALC is responsible for the lysosomal catabolism of certain galactolipids, including galactosylceramide and psychosine.

References

References

  1. (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America.
  2. (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure.
  3. (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal.
  4. "Home".
  5. (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research.
  6. "Glycoside Hydrolase Family 59".
  7. (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology.
  8. (1996). "Cloning of the canine GALC cDNA and identification of the mutation causing globoid cell leukodystrophy in West Highland White and Cairn terriers". Genomics.
  9. (1995). "Structure and organization of the human galactocerebrosidase (GALC) gene". Genomics.
  10. (1998). "Human galactocerebrosidase gene: promoter analysis of the 5'-flanking region and structural organization". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.
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