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Glycoside hydrolase family 25

FieldValue
SymbolGlyco_hydro_25
NameGlycosyl hydrolases family 25
imagePDB 1jfx EBI.jpg
captioncrystal structure of the bacterial lysozyme from streptomyces coelicolor at 1.65 a resolution
PfamPF01183
Pfam_clanCL0058
InterProIPR002053
PROSITEPDOC00737
SCOP1jfx
CAZyGH25

In molecular biology, glycoside hydrolase family 25 is a family of glycoside hydrolases.

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of 100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

Glycoside hydrolase family 25 CAZY GH_25 comprises enzymes with only one known activity; lysozyme (). It has been shown that a number of cell-wall lytic enzymes are evolutionary related and can be classified into a single family. Two residues, an aspartate and a glutamate, have been shown to be important for the catalytic activity of the Charalopsis enzyme. These residues as well as some others in their vicinity are conserved in all proteins from this family.

References

References

  1. (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America.
  2. (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure.
  3. (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal.
  4. "Home".
  5. (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research.
  6. "Glycoside Hydrolase Family 25".
  7. (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology.
  8. (December 1991). "A classification of glycosyl hydrolases based on amino acid sequence similarities". The Biochemical Journal.
  9. (July 1991). "Sequence of the lyc gene encoding the autolytic lysozyme of Clostridium acetobutylicum ATCC824: comparison with other lytic enzymes". Gene.
  10. (October 1978). "The N,O-diacetylmuramidase of Chalaropsis species. Identification of aspartyl and glutamyl residues in the active site". The Journal of Biological Chemistry.
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ec-3.2.1 glycoside-hydrolase-families protein-families
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