From Surf Wiki (app.surf) — the open knowledge base

Glycoside hydrolase family 19

Enzyme

Field	Value
Symbol	Glyco_hydro_19
Name	Glycosyl hydrolases family 19
image	PDB 2baa EBI.jpg
caption	the refined crystal structure of an endochitinase from hordeum vulgare l. seeds to 1.8 angstroms resolution
Pfam	PF00182
Pfam_clan	CL0037
InterPro	IPR000726
PROSITE	PDOC00620
SCOP	2baa
CAZy	GH19
CDD	cd00325

In molecular biology, Glycoside hydrolase family 19 is a family of glycoside hydrolases , which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of 100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. y[ _]9

Glycoside hydrolase family 19 CAZY GH_19 comprises enzymes with only one known activity; chitinase ().

Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Chitinases belong to glycoside hydrolase families 18 or 19. Chitinases of family 19 (also known as classes IA or I and IB or II) are enzymes from plants that function in the defence against fungal and insect pathogens by destroying their chitin-containing cell wall. Class IA/I and IB/II enzymes differ in the presence (IA/I) or absence (IB/II) of a N-terminal chitin-binding domain. The catalytic domain of these enzymes consist of about 220 to 230 amino acid residues.

Active site

doi-access = free }}</ref> Conserved residues are shown surrounding the catalytic acid, Glu67. A GlcNAc2 unit binding in the -1 and +1 subsites is shown in narrow stick representation and an arrow indicates the position of the glycosidic oxygen.

GH19 enzymes has a conserved sequence motif ([FHY]-G-R-G-[AP]-ζ-Q-[IL]-[ST]-[FHYW]-[HN]-[FY]-[NY], ζ= hydrophilic amino acid) in its active site.

References

(July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America.
(September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure.
(June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal.
"Home".
(January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research.
"Glycoside Hydrolase Family 19".
CAZypedia Consortium. (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology.
(August 1992). "What's new in chitinase research?". Experientia.
(December 1991). "A classification of glycosyl hydrolases based on amino acid sequence similarities". The Biochemical Journal.
(2010-01-01). "Structure and function of enzymes acting on chitin and chitosan". Biotechnology & Genetic Engineering Reviews.
(May 2010). "Evolution, homology conservation, and identification of unique sequence signatures in GH19 family chitinases". Journal of Molecular Evolution.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-3.2.1 glycoside-hydrolase-families protein-families

Want to explore this topic further?

Ask Mako anything about Glycoside hydrolase family 19 — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report