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Glycine/sarcosine N-methyltransferase

FieldValue
NameGlycine/sarcosine N-methyltransferase
EC_number2.1.1.156
CAS_number294210-82-5

Glycine/sarcosine N-methyltransferase (, ApGSMT, glycine-sarcosine methyltransferase, GSMT, GMT, glycine sarcosine N-methyltransferase, S-adenosyl-L-methionine:sarcosine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase (sarcosine(or N,N-dimethylglycine)-forming). This enzyme catalyses the following chemical reaction

: 2 S-adenosyl-L-methionine + glycine \rightleftharpoons 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine (overall reaction) :(1a) S-adenosyl-L-methionine + glycine \rightleftharpoons S-adenosyl-L-homocysteine + sarcosine :(1b) S-adenosyl-L-methionine + sarcosine \rightleftharpoons S-adenosyl-L-homocysteine + N,N-dimethylglycine

This enzyme participates in biosynthesis of betaine from glycine in cyanobacterium Aphanocthece halophytica.

References

References

  1. (July 2000). "Extreme halophiles synthesize betaine from glycine by methylation". The Journal of Biological Chemistry.
  2. (May 2001). "Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase". Applied and Environmental Microbiology.
  3. (February 2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". The Journal of Biological Chemistry.
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