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Gliomatosis cerebri

FieldValue
nameGliomatosis cerebri
synonymsInfiltrative diffuse astrocytosis
imageGliomatosis cerebri.jpg
captionAxial fluid-attenuated inversion recovery MRI image demonstrating tumor-related infiltration involving both temporal lobes (Short arrow), and the substantia nigra (Long arrow).
fieldNeuro-oncology, Neurosurgery

Previously it was considered to be a separate type of tumor, but this view has been overturned by molecular and genetic diagnostics.

Definition

As defined by the WHO, gliomatosis cerebri spans at least three cerebral lobes, usually involves both hemispheres and can also spread deeply into the gray matter or into infratentorial structures like the brainstem, cerebelleum or spinal cord.

Until the 4th revision of the WHO classification of tumours of the central nervous system of 2016, gliomatosis cerebri was considered to be a distinct entity. Due to advances in molecular diagnostics, the lack of a specific genetic profile and poor prognostic value, this definition is now considered obsolete.

Causes

Gliomatosis cerebri is most often caused by glioblastoma, but can also arise from astrocytoma, oligodendroglioma or other types of diffuse glioma. Other pathologies such as vasculitis, encephalitis or leukoencephalopathy may also cause similar radiological findings.

Notes

References

  1. (2016). "WHO classification of tumours of the central nervous system". International Agency for Research on Cancer.
  2. (March 2020). "Clinical relevance of molecular subgrouping of gliomatosis cerebri per 2016 WHO classification: a clinicopathological study of 89 cases". Brain Pathology.
  3. (February 2014). "Gliomatosis Cerebri: A Review". Current Treatment Options in Neurology.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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