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Gangliocytic paraganglioma

FieldValue
nameGangliocytic paraganglioma
imageGangliocytic_paraganglioma_-_2_-_high_mag.jpg
captionMicrograph of a gangliocytic paraganglioma. H&E stain.
pronounceGP
fieldPathology

A gangliocytic paraganglioma is a rare tumour that is typically found in the duodenum and consists of three components: (1) ganglion cells, (2) epithelioid cells (paraganglioma-like) and, (3) spindle cells (schwannoma-like).

Symptoms and signs

The most common presentation is gastrointestinal bleed (~45% of cases), followed by abdominal pain (~43% of cases) and anemia (~15% of cases).

Pathology

GP consist of three components (1) ganglion cells, (2) epithelioid cells (neuroendocrine-like), and (3) spindle cells (schwannoma-like). The microscopic differential diagnosis includes poorly differentiated carcinoma, neuroendocrine tumour and paraganglioma.

GPs may be sporadic or arise in the context neurofibromatosis type 1. Image: Gangliocytic paraganglioma - intermed mag.jpg | Intermed. mag. Image: Gangliocytic paraganglioma - 2 - intermed mag.jpg | Intermed. mag. Image: Gangliocytic paraganglioma - very high mag.jpg | Very high mag. Image: Gangliocytic paraganglioma - 2 - very high mag.jpg | Very high mag.

References

References

  1. (Mar 2005). "Locally advanced duodenal gangliocytic paraganglioma treated with adjuvant radiation therapy: case report and review of the literature". World J Surg Oncol.
  2. (2011). "Literature survey on epidemiology and pathology of gangliocytic paraganglioma". BMC Cancer.
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