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Galactitol

Galactitol (dulcitol) is a sugar alcohol, the reduction product of galactose. It has a slightly sweet taste.

Galactitol is produced from galactose in a reaction catalyzed by aldose reductase.

The other common galactose metabolism defect is a defect in galactose-1-phosphate uridylyltransferase, an autosomal recessive disorder, which also causes a buildup of galactitol as a result of increased concentrations of galactose-1-phosphate and galactose. This disorder leads to cataracts caused by galactitol buildup.

References

References

  1. "Galactitol - Compound Summary". [[National Center for Biotechnology Information]].
  2. Roth, KS. (September 10, 2007). "Galactokinase Deficiency". [[WebMD]].
  3. Narayanan, S.. (1993-03-01). "Aldose reductase and its inhibition in the control of diabetic complications". Annals of Clinical & Laboratory Science.
  4. Palmieri, Michael. (1999-10-01). "Urine and plasma galactitol in patients with galactose-1-phosphate uridyltransferase deficiency galactosemia". Metabolism.
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sugar-alcohols sugar-substitutes
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