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Folliculosebaceous cystic hamartoma

FieldValue
imageSkinTumors-P7080424.JPG
captionAdnexoblastic (folliculosebaceous) trichoid hamartoma
specialtyDermatology

Folliculosebaceous cystic hamartoma abbreviated as (FSCH) is a rare cutaneous hamartoma consisting of dilated folliculosebaceous units invested in mesenchymal elements. it typically affects adults, have a predilection for the central face or scalp, with less than 1.5 cm dimension. Clinically, the lesions are asymptomatic, rubbery to firm in consistency, and usually occur on or above the neck in ( 90%) of cases, Histopathologically, FSCH shares several similar features to sebaceous trichofolliculoma, but it is usually possible to differentiate these two tumors.

Signs and symptoms

Folliculosebaceous cystic hamartomas frequently manifests as a flesh-colored papule or nodule that is asymptomatic. Folliculosebaceous cystic hamartomas are usually found on the scalp or central face. The lesions are usually 0.5–1.5 cm flesh-colored, exophytic, solitary, rubbery or firm, and partially umbilicated.

Diagnosis

The typical histopathologic features of folliculosebaceous cystic hamartoma lesions are mesenchymal, follicular, and sebaceous elements; these lesions frequently manifest as sebaceous structures that emerge from a core infundibular cyst that is contained inside the dermis. Mesenchymal alterations are frequently observed throughout the stroma and are characterized by fibrillary bundles of collagen with proliferating adipocytes, as well as a rise in capillaries and tiny venules. There are clefts separating the neighboring dermis from the epithelial component. In the stroma of lesions, immature adipocytes with lipid droplets and spindle- or starry-shaped nuclei have been observed; these cells are frequently located close to the sebaceous formations.

References

References

  1. (2006). "Andrews' Diseases of the Skin: Clinical Dermatology". Saunders Elsevier.
  2. (October 2008). "Giant, congenital folliculosebaceous cystic hamartoma: a case against a pathogenetic relationship with trichofolliculoma". [[Am J Dermatopathol]].
  3. (January 2006). "Two cases of folliculosebaceous cystic hamartoma". [[Clin. Exp. Dermatol.]].
  4. Nguyen, Catherine M.. (2015). "Folliculosebaceous Cystic Hamartoma With Spindle Cell Lipoma-Like Stromal Features". Ovid Technologies (Wolters Kluwer Health).
  5. Ansai, Shin-ichi. (2010). "A Clinicopathologic Study of Folliculosebaceous Cystic Hamartoma". The American Journal of Dermatopathology.
  6. Suarez‐Peñaranda, Jose M.. (2009-01-20). "Clinicopathological and immnuohistochemical findings in a series of folliculosebaceous cystic hamartoma". Wiley.
  7. Misago, Noriyuki. (2010). "A Revaluation of Folliculosebaceous Cystic Hamartoma: The Histopathological and Immunohistochemical Features". Ovid Technologies (Wolters Kluwer Health).
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epidermal-nevi,-neoplasms,-and-cysts
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