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Folate transporter 1

Mammalian protein found in Homo sapiens

Mammalian protein found in Homo sapiens

Folate transporter 1 is a protein which in humans is encoded by the SLC19A1 gene.

Function

Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate. SLC19A1 has also been shown to transport the immune second messenger 2'3'-cGAMP.

Clinical significance

Individuals carrying a specific polymorphism of SLC19A1 (c.80GG) have lower levels of folate.

  • Other studies have also shown that individuals carrying the c.80AA polymorphism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent. Personalized dosing of the drug depending on the patient's genotype may therefore be required.

Alternative names

  • Reduced folate carrier 1
  • Intestinal folate carrier 1

References

References

  1. (April 1998). "Construction of a 2.5-Mb integrated physical and gene map of distal 21q22.3". Genomics.
  2. "Entrez Gene: SLC19A1 solute carrier family 19 (folate transporter), member 1".
  3. (25 July 2019). "SLC19A1 Is an Importer of the Immunotransmitter cGAMP.". Molecular Cell.
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