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Flocoumafen

Flocoumafen is a fluorinated, second-generation anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It is a second generation (i.e., high potency) chemical in this class, used commercially as a rodenticide. It has a very high toxicity and is restricted to indoor use and sewers (in the UK). This restriction is mainly due to the increased risk to non-target species, especially due to its tendency to bio-accumulate in exposed organisms. Studies have shown that rodents resistant to first-generation anticoagulants can be adequately controlled with flocoumafen.

Toxicity

In most rodents, the is 1 mg/kg, but it can vary between species: from 0.12 mg/kg in the common vole (Microtus arvalis) to more than 10 mg/kg in the Cairo spiny mouse (Acomys cahirinus). For dogs the LD50 is 0.075-0.25 mg/kg.

Antidote

The antidote to flocoumafen is vitamin K1, which must be administered over a period of several weeks or even months.

References

References

  1. (2005). "Anticoagulant Rodenticides". Toxicological Reviews.
  2. It was synthesized in 1984 by [[Shell Chemicals
  3. "Flocoumafen: Antidote and Emergency Treatment". [[PubChem]].
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

rodenticides phenol-ethers trifluoromethyl-compounds chromones tetralins hydroxyarenes vitamin-k-antagonists anticoagulant-rodenticides 4-hydroxycoumarins
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