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Fixed drug reaction

Field	Value
name	Fixed drug reaction
synonyms	Drug eruption
image	Drug eruption2.jpg
caption	Fixed drug eruption caused by phenolphthalein

Fixed drug reactions are common and so named because they recur at the same site with each exposure to a particular medication. Medications inducing fixed drug eruptions are usually those taken intermittently.

Signs and symptoms

A painful and itchy reddish/purple patch of skin that occurs in the same location with repeated exposures to the causative drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.

Cause

Medications that are commonly implicated as a cause of fixed drug eruptions include the following:

Cetirizine
Ciprofloxacin
Clarithromycin
Cotrimoxazole
Doxycycline
Fluconazole
NSAIDs (e.g., ibuprofen, etoricoxib, naproxen)
Phenytoin
Pseudoephedrine
Trimethoprim

References

(2005). "Andrews' Diseases of the Skin: Clinical Dermatology". Saunders.
(April 1998). "Nonpigmenting fixed drug eruption due to pseudoephedrine". Annals of Allergy, Asthma & Immunology.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

drug-eruptions

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