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Fibrous cap

Layer found in atheromatous plaques

Fibrous cap
Summary

Layer found in atheromatous plaques

Fibrous cap in an [[atheromatous plaque

The fibrous cap is a layer of fibrous connective tissue, which is thicker and less cellular than the normal intima, found in atheromatous plaques. The fibrous cap contains macrophages and smooth muscle cells. The fibrous cap of an atheroma is composed of bundles of muscle cells, macrophages, foam cells, lymphocytes, collagen and elastin. An atheroma with a cap is termed a fibrous cap atheroma.

Rupture

Histopathological progresssion

The rupture of a fibrous cap can lead to a stroke, or a heart attack either of which has the potential to be fatal. The fibrous cap is prone to rupture and ulceration which can lead to thrombosis. In advanced lesions, further complications may arise including calcification of the fibrous cap.

References

References

  1. Hansson, Göran K.. (July 2006). "The immune response in atherosclerosis: a double-edged sword". Nature Reviews Immunology.
  2. (31 March 2022). "Tissue-engineered collagenous fibrous cap models to systematically elucidate atherosclerotic plaque rupture".
  3. Swirski, F. K.. (10 January 2013). "Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure". Science.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

angiology
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