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Fezolamine

Chemical compound

Summary

Chemical compound

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Fezolamine (Win-41,528-2) is a drug which was investigated by Sterling Drug as an antidepressant in the 1980s. The isomeric N,N-dimethyl-4,5-diphenyl-1H-pyrazole-1-propanamine was completely inactive in the primary antidepressant screens.

It acts as a serotonin, norepinephrine, and dopamine reuptake inhibitor, with 3- to 4-fold preference for the former neurotransmitter. It was found to be effective and well tolerated in clinical trials but was never marketed.

Changing the sidechain leads to an agent called ipazilide.

References

{{US Patent. 4182895
(February 1985). "3,4-Diphenyl-1H-pyrazole-1-propanamine antidepressants". Journal of Medicinal Chemistry.
(October 1987). "Pharmacologic profile of fezolamine fumarate: a nontricyclic antidepressant in animal models". The Journal of Pharmacology and Experimental Therapeutics.
(1987). "Efficacy and safety of fezolamine in depressed patients". Neuropsychobiology.

Wikipedia Source

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dimethylamino-compounds serotonin–norepinephrine-reuptake-inhibitors pyrazoles

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