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Fenarimol

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Fenarimol, sold under the tradenames Bloc, Rimidin and Rubigan, is a fungicide which acts against rusts, blackspot and mildew fungi. It is used on ornamental plants, trees, lawns, tomatoes, peppers, eggplants, cucumbers and melons. It is mainly used to control powdery mildew. It works by inhibiting the fungus's biosynthesis of important steroid molecules (via blockade of the CYP51 enzyme).

History

Fenarimol was developed by Eli Lilly and Company around 1971.

Derivatives of this compound are being researched in an open source manner for possible treatment of eumycetoma.

Synthesis

Fenarimol is made by the reaction of 2,4'-dichlorobenzophenone with an organolithium pyrimidine made via bromine-lithium exchange. :[[File:Fenarimolsynth.svg|Fenarimolsynth]]

References

References

  1. [http://ec.europa.eu/food/plant/protection/evaluation/existactive/list_fenarimol.pdf EU-Data].
  2. (2005). "Organic chemistry". Oxford Univ. Press.
  3. {{patent. GB. 1218623. "Substituted-5-pyrimidine compounds "
  4. (2018). "Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma". PLOS Neglected Tropical Diseases.
  5. (2025). "Structure–activity relationships of fenarimol analogues with potent in vitro and in vivo activity against Madurella mycetomatis , the main causative agent of mycetoma". RSC Medicinal Chemistry.
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aromatase-inhibitors 2-chlorophenyl-compounds endocrine-disruptors fungicides nonsteroidal-antiandrogens pyrimidines xenoestrogens 4-chlorophenyl-compounds tertiary-alcohols
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