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Fananserin

Chemical compound

Summary

Chemical compound

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Fananserin (RP-62203) is a drug which acts as a potent antagonist at both the serotonin 5-HT2A receptor, and the dopamine D4 receptor, but without blocking other dopamine receptors such as the dopamine D2 receptor. It has sedative and antipsychotic effects, and has been researched for the treatment of schizophrenia, although efficacy was less than expected and results were disappointing.

References

References

  1. (August 1991). "Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists". Journal of Medicinal Chemistry.
  2. (October 1996). "The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor". European Journal of Pharmacology.
  3. (January 1992). "Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist". British Journal of Pharmacology.
  4. (April 1992). "RP 62203, a 5-hydroxytryptamine2 antagonist, enhances deep NREM sleep in rats". Sleep.
  5. (1998). "A bridging study of fananserin in schizophrenic patients". Psychopharmacology Bulletin.
  6. (March 1999). "Placebo-controlled study of the D4/5-HT2A antagonist fananserin in the treatment of schizophrenia". The American Journal of Psychiatry.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

antipsychotics 4-fluorophenyl-compounds piperazines nitrogen-heterocycles sulfur-heterocycles d4-antagonists 5-ht2a-antagonists sultams heterocyclic-compounds-with-3-rings arylsulfonamides
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