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FAD-dependent urate hydroxylase

Class of enzymes

Field	Value
Name	FAD-dependent urate hydroxylase
EC_number	1.14.13.113

FAD-dependent urate hydroxylase (, HpxO enzyme, FAD-dependent urate oxidase, urate hydroxylase) is an enzyme with systematic name urate,NADH:oxygen oxidoreductase (5-hydroxyisourate forming). A non-homologous isofunctional enzyme (NISE) to HpxO was found, and named HpyO. HpyO was determined to be a typical Michaelian enzyme. These FAD-dependent urate hydroxylases are flavoproteins.

This enzyme catalyses the following chemical reaction

: urate + FADH + H+ + O2 \rightleftharpoons 5-hydroxyisourate + FAD+ + H2O

References

(2009). "Biochemical characterization of the HpxO enzyme from ''Klebsiella pneumoniae'', a novel FAD-dependent urate oxidase". Biochemistry.
(2008). "The hpx genetic system for hypoxanthine assimilation as a nitrogen source in ''Klebsiella pneumoniae'': gene organization and transcriptional regulation". Journal of Bacteriology.
(2012). "Microbial urate catabolism: characterization of HpyO, a non-homologous isofunctional isoform of the flavoprotein urate hydroxylase HpxO". Environmental Microbiology Reports.

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ec-1.14.13

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