Eugene Koonin

Education

Koonin gained a Master of Science in 1978 and a PhD in 1983 in molecular biology, both from the Department of Biology at Moscow State University. His PhD thesis, titled "Multienzyme organization of encephalomyocarditis virus replication complexes", was supervised by Vadim I. Agol.

Research

From 1985 until 1991, Koonin worked as a research scientist in computational biology in the Institutes of Poliomyelitis and Microbiology at the USSR Academy of Medical Sciences, studying virus biochemistry and bacterial genetics. In 1991, Koonin moved to the NCBI, where he has held a Senior Investigator position since 1996.

Koonin's principal research goals include the comparative analysis of sequenced genomes and automatic methods for genome-scale annotation of gene functions. He also researches in the application of comparative genomics for phylogenetic analysis, reconstruction of ancestral life forms and building large-scale evolutionary scenarios, as well as mathematical modeling of genome evolution. Koonin's research also investigates computational study of the major transitions in the evolution of life, such as the origin of eukaryotes, the evolution of eukaryotic signaling and developmental pathways from the comparative-genomic perspective.{{Cite journal | doi-access = free

Koonin is an advocate of the extended evolutionary synthesis.

In 2011 Koonin outlined his views on evolution in the book "The Logic of Chance: The Nature and Origin of Biological Evolution".

In 2025, Koonin contributed to the discovery of TIGR-Tas, a family of ancient RNA-guided DNA-targeting systems.

Career

Koonin has worked as adjunct professor at the Georgia Institute of Technology, Boston University and the University of Haifa.

As of 2014, Koonin serves on the advisory editorial board of Trends in Genetics, and is co-Editor-in-Chief of the open access journal Biology Direct. He served on the editorial board of Bioinformatics from 1999 until 2001. Koonin is also an advisory board member in bioinformatics at Faculty of 1000.

In 2016 he was elected to the National Academy of Sciences.

In 2016, Semantic Scholar AI program included Koonin on its list of top ten most influential biomedical researchers.

Political positions

In February 2022, he signed an open letter by Russian scientists condemning the 2022 Russian invasion of Ukraine, and renounced his membership in the Russian Academy of Sciences out of protest.

References

Selected bibliography

• HAL Id: 02861246.

References

1. https://www.ncbi.nlm.nih.gov/CBBresearch/Koonin/ Koonin's page at the National Center for Biotechnology Information
2. Eugene V. Koonin. (23 June 2011). "The Logic of Chance: The Nature and Origin of Biological Evolution". FT Press.
3. "CV E. Koonin".
4. (Feb 2001). "Initial sequencing and analysis of the human genome". Nature.
5. (2011). "Are There Laws of Genome Evolution?". [[PLOS Computational Biology]].
6. (2007). "The Biological Big Bang model for the major transitions in evolution". Biology Direct.
7. (2006). "The ancient Virus World and evolution of cells". Biology Direct.
8. (2006). "Introns and the origin of nucleus–cytosol compartmentalization". Nature.
9. (2023). "Evolutionary Biology: Contemporary and Historical Reflections Upon Core Theory".
10. (February 2025). "TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses". Science.
11. Michalowski, Jennifer. (February 27, 2025). "An ancient RNA-guided system could simplify delivery of gene editing therapies". McGovern Institute for Brain Research.
12. "Faculty and Researchers".
13. "Masthead: Trends in Genetics".
14. "Biology Direct – Editorial Board".
15. "Eugene Koonin: Advisory Board Member in Bioinformatics – F1000Prime".
16. (May 3, 2016). "National Academy of Sciences Members and Foreign Associates Elected". [[National Academy of Sciences]].
17. Gabrielsen, Paul. (2017-01-31). "Profile of Eugene V. Koonin". [[Proceedings of the National Academy of Sciences of the United States of America]].
18. (17 October 2017). "Who's the most influential biomedical scientist? Computer program guided by artificial intelligence says it knows".
19. (24 February 2022). "Открытое письмо российских учёных и научных журналистов против войны с Украиной".
20. "Global Science Community Condemns Russian Invasion of Ukraine".