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Ethinylestradiol/norethisterone acetate

Pharmaceutical combination

Pharmaceutical combination

FieldValue
typecombo
component1Ethinylestradiol
class1Estrogen
component2Norethisterone acetate
class2Progestogen
tradenameFemlyv, Estrostep, Loestrin, Microgestin, others
Drugs.com
DailyMedIDNorethindrone acetate and ethinyl estradiol
pregnancy_AU
routes_of_administrationBy mouth
ATC_prefixG03
ATC_suffixAB04
legal_AU
legal_BR
legal_CARx-only
legal_CA_comment
legal_DE
legal_NZ
legal_UK
legal_USRx-only
legal_UN
legal_status
CAS_number8015-12-1
PubChem63020
KEGGD04483
synonymsEE/NETA
SMILESCC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C)C#C.CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O
StdInChI1S/C22H28O3.C20H24O2/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3;1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,13,17-20H,5-12H2,2-3H3;1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t17-,18+,19+,20-,21-,22-;16-,17-,18+,19+,20+/m01/s1
StdInChIKeyGEONECATAKDDLT-JDSZYESASA-N

| Drugs.com =

Ethinylestradiol/norethisterone acetate (EE/NETA), or ethinylestradiol/norethindrone acetate, is a combination of ethinylestradiol (EE) and norethisterone acetate (NETA) which is used as birth control and menopausal hormone therapy. EE is an estrogen, while norethisterone acetate (NETA) is a progestin.

Norethindrone acetate and ethinyl estradiol have been approved in the US for the prevention of pregnancy as a swallowable tablet since 1968. In 2022, the combination of ethinylestradiol with norethisterone or with norethisterone acetate was the 80th most commonly prescribed medication in the United States, with more than 8million prescriptions. It is available as a generic medication.

Medical uses

Ethinylestradiol/norethisterone acetate is indicated for use by females of reproductive potential to prevent pregnancy.

Ethinylestradiol/norethisterone acetate is also indicated in women with an intact uterus for the treatment of moderate to severe vasomotor symptoms associated with the menopause; and for prevention of postmenopausal osteoporosis.

Society and culture

In July 2024, the US Food and Drug Administration (FDA) approved Femlyv, the first orally disintegrating tablet for the prevention of pregnancy. Norethindrone acetate and ethinyl estradiol have been approved in the US for the prevention of pregnancy as a swallowable tablet since 1968.

Brand names

Brand names include Anovlar, Blisovi, Cumorit, Estrostep, Femhrt, Femlyv, Fyavolv, Gildess, Junel, Larin, Leribane, Loestrin, Lo Loestrin (Lo Lo), Mibelas, Microgestin, Minastrin, Norlestrin, Primodos, Taytulla, and Tri-Legest, among others.

References

References

  1. (6 May 2024). "Lolo Product information".
  2. "Estrogen-Progestin Combinations Monograph for Professionals". AHFS.
  3. (June 2006). "Effects of low-dose norethindrone acetate plus ethinyl estradiol (0.5 mg/2.5 microg) in women with postmenopausal symptoms: updated analysis of three randomized, controlled trials". Clin Ther.
  4. (1 May 2014). "Basic Pharmacology for Nurses - E-Book". Elsevier Health Sciences.
  5. "The Top 300 of 2022".
  6. "Ethinyl Estradiol; Norethindrone Drug Usage Statistics, United States, 2013 - 2022".
  7. (29 June 2023). "Competitive Generic Therapy Approvals".
  8. "Femlyv Full Prescribing Information".
  9. (14 November 2017). "Femhrt- norethindrone acetate/ethinyl estradiol tablet".
  10. "Drug Approval Package: Femhrt (Norethindrone Acetate & Ethinyl Estradiol) NDA #21065".
  11. (23 July 2024). "FDA Roundup: July 23, 2024".
  12. (14 August 2023). "Junel 21 Day- norethindrone acetate and ethinyl estradiol tablet; Junel Fe 28 Day- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit".
  13. (13 July 2019). "Ethinyl Estradiol and Norethindrone (Professional Patient Advice)".
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