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Estropipate

Estrogen medication

Summary

Estrogen medication

| Drugs.com =

| elimination_half-life =

Estropipate, also known as piperazine estrone sulfate and sold under the brand names Harmogen, Improvera, Ogen, Ortho-Est, and Sulestrex among others, is an estrogen medication which is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms. It is a salt of estrone sulfate and piperazine, and is transformed into estrone and estradiol in the body. It is taken by mouth.

Medical uses

Estropipate is used to:

  • Alleviate symptoms of menopause as menopausal hormone therapy
  • Treat some types of infertility
  • Treat some conditions leading to underdevelopment of female sexual characteristics
  • Treat vaginal atrophy
  • Treat some types of breast cancer (particularly in men and postmenopausal women)
  • Treat prostate cancer
  • Prevent osteoporosis

Available forms

Estropipate was available in the form of 0.75, 1.5, 3, and 6 mg oral tablets and 1.5 mg/gram vaginal cream. Estropipate is no longer available in the United States.

Pharmacology

Pharmacodynamics

Estropipate is a prodrug of estrone and estradiol. Hence, it is an estrogen, or an agonist of the estrogen receptors.

Pharmacokinetics

Estropipate is hydrolyzed into estrone in the body. Estrone can then be transformed into estradiol by 17β-hydroxysteroid dehydrogenase.

Chemistry

History

Estropipate was introduced for medical use by Abbott in 1968. It was approved by the in the United States in 1991.

Society and culture

Generic names

Estropipate is the generic name of the drug and its , , and .

Brand names

Estropipate was marketed under the brand names Genoral, Harmogen, Improvera, Ogen, Ortho-Est, and Sulestrex among others.

Availability

Estropipate has been discontinued in the United States. In the past, estropipate has also been marketed in Canada, the United Kingdom, Ireland, Switzerland, Australia, South Africa, Mexico, and Indonesia.

References

References

  1. (December 2004). "Ogen, estropipate tablets, USP". U.S. Food and Drug Administration.
  2. (14 November 2014). "The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies". Springer.
  3. (6 December 2012). "Concise Dictionary of Pharmacological Agents: Properties and Synonyms". Springer Science & Business Media.
  4. William Andrew Publishing. (22 October 2013). "Pharmaceutical Manufacturing Encyclopedia". Elsevier.
  5. Budoff, Penny Wise. (1 August 1983). "No more hot flashes, and other good news". Putnam.
  6. (July 1993). "P & T.". CORE Medical Journals.
  7. (2000). "Index Nominum 2000: International Drug Directory". Taylor & Francis.
  8. (2009). "Martindale: The Complete Drug Reference". Pharmaceutical Press.
  9. "Estropipate". Drugs.com.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

estranes estrone-esters ketones piperazines organosulfates salts synthetic-estrogens
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