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EMR3

Protein-coding gene in the species Homo sapiens

Protein-coding gene in the species Homo sapiens

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene. EMR3 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human. Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain. Mice, next to Emr2, lack the Emr3 gene.

Function

The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.

Ligands

A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.

References

References

  1. (June 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry.
  2. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews.
  3. Stacey M, Yona S. (2011). "Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology)". Springer.
  4. (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling.
  5. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal.
  6. (February 2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes". Journal of Leukocyte Biology.
  7. (June 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry.
  8. (December 2006). "An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2". FASEB Journal.
  9. "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3".
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