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Elvitegravir/cobicistat/emtricitabine/tenofovir

Combination drug for HIV

Summary

Combination drug for HIV

the combination medication elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil

| Drugs.com =

Elvitegravir/cobicistat/emtricitabine/tenofovir, sold under the brand name Stribild, also known as the Quad pill, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. Elvitegravir, emtricitabine and tenofovir disoproxil directly suppress viral reproduction. Cobicistat increases the effectiveness of the combination by inhibiting the liver and gut wall enzymes that metabolize elvitegravir. It is taken by mouth. It is manufactured by Gilead Sciences.

Serum creatinine (a marker of kidney function) may increase with use of elvitegravir/cobicistat/emtricitabine/tenofovir. This is caused by cobicistat's inhibition of tubular secretion in the nephron.

Society and culture

Elvitegravir/cobicistat/emtricitabine/tenofovir gained approval by the U.S. Food and Drug Administration (FDA) in August 2012, for use in adults starting antiretroviral treatment for the first time as part of the fixed dose combination.

Economics

Gilead's stated wholesale price of Stribild is per patient, per year. Gilead maintains that its pricing is comparable to other HIV medications on the market. Elvitegravir/cobicistat/emtricitabine/tenofovir (Stribild) is priced at 39 percent higher than emtricitabine/rilpivirine/tenofovir (Complera), a three-drug HIV regimen approved a year earlier. At the time of Complera's approval, there were concerns about the wholesale cost of efavirenz/emtricitabine/tenofovir (Atripla), which is marketed by Gilead and Bristol-Myers Squibb. HIV drug prices have increased substantially. Atripla, a combination therapy released in 2006, was priced at per person, per year. Atripla's wholesale prices have risen to the level of Complera's at .

References

References

  1. (16 September 2021). "Stribild- elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate tablet, film coated".
  2. (13 June 2013). "Stribild EPAR".
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

cyp3a4-inhibitors fixed-dose-combination-(antiretroviral) gilead-sciences hepatotoxins
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