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Ellagitannin

Diverse class of hydrolyzable tannins, a type of polyphenol

Diverse class of hydrolyzable tannins, a type of polyphenol

thumb|right|130px|[[Castalagin]] is a representative ellagitannin, characterized by coupled gallic acid substituents The ellagitannins are a diverse class of hydrolyzable tannins, a type of polyphenol formed primarily from the oxidative linkage of galloyl groups in 1,2,3,4,6-pentagalloyl glucose. Ellagitannins differ from gallotannins, in that their galloyl groups are linked through C-C bonds, whereas the galloyl groups in gallotannins are linked by depside bonds.

Ellagitannins contain various numbers of hexahydroxydiphenoyl units, as well as galloyl units and/or sanguisorboyl units bounded to sugar moiety. In order to determine the quantity of every individual unit, the hydrolysis of the extracts with trifluoroacetic acid in methanol/water system is performed. Hexahydroxydiphenic acid, created after hydrolysis, spontaneously lactonized to ellagic acid, and sanguisorbic acid to sanguisorbic acid dilactone, while gallic acid remains intact.

Ellagitannins generally form macrocycles, whereas gallotannins do not.

Examples

  • Castalagin
  • Castalin
  • Casuarictin
  • Grandinin
  • Oenothein B from Willowherbs (Epilobium spp.)
  • Roburin A
  • Tellimagrandin II
  • Terflavin B
  • Vescalagin
  • Pomegranate ellagitannins, many compounds
    • Punicalagin
    • Punicalin

Metabolism

Degradation

Urolithins, such as urolithin A, are microflora human metabolites of dietary ellagic acid derivatives.

Natural occurrences

Ellagitannins are reported in dicotyledoneous angiospermes, and notably in species in the order Myrtales, such as the pomegranate.

References

References

  1. (2011). "Ellagitannins, ellagic acid and their derived metabolites: A review about source, metabolism, functions and health". Food Research International.
  2. Structural diversity and antimicrobial activities of ellagitannins. T. Yoshida, Ts. Hatano, H. Ito, T. Okuda, S. Quideau (Ed.), Chemistry and Biology of Ellagitannins, World Scientific Publishing, Singapore (2009), pages 55–93
  3. (Oct 2009). "Gastrointestinal microflora, food components and colon cancer prevention". J Nutr Biochem.
  4. Yoshida, Takashi. (2010). "Structural Features and Biological Properties of Ellagitannins in Some Plant Families of the Order Myrtales". International Journal of Molecular Sciences.
  5. (2013). "Determination of the major phenolic compounds in pomegranate juices by HPLC−DAD−ESI-MS". Journal of Agricultural and Food Chemistry.
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