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Duffy binding proteins

Field	Value
Symbol	Duffy_binding
Name	Duffy binding domain
image	PDB 1zro EBI.jpg
caption	crystal structure of eba-175 region ii (rii) crystallized in the presence of (alpha)2,3-sialyllactose
Pfam	PF05424
Pfam_clan	CL0195
InterPro	IPR008602

In molecular biology, Duffy binding proteins are found in Plasmodium. Plasmodium vivax and Plasmodium knowlesi merozoites invade Homo sapiens erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa.{{Cite journal | doi-access = free

The presence of duffy-binding-like domains defines the family of erythrocyte binding-like proteins (EBL), a family of cell invasion proteins universal among Plasmodium. These other members may use some other receptor, for example Glycophorin A. The other universal invasion protein is reticulocyte binding protein homologs. Both families are essential for cell invasion, as they function cooperatively.

A duffy-binding-like domain is also found in proteins of the family Plasmodium falciparum erythrocyte membrane protein 1.

References

(October 1990). "The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites". Cell.
(July 2007). "Invasion of host cells by malaria parasites: a tale of two protein families". Molecular Microbiology.
(March 2011). "Reticulocyte and Erythrocyte Binding-Like Proteins Function Cooperatively in Invasion of Human Erythrocytes by Malaria Parasites". Infection and Immunity.

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