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DSS1/SEM1 protein family

FieldValue
SymbolDSS1_SEM1
NameDSS1_SEM1
imagePDB 1miu EBI.jpg
captionstructure of a brca2-dss1 complex
PfamPF05160
InterProIPR007834
SCOP1iyj

In molecular biology, the DSS1/SEM1 protein family is a family of short acidic proteins which includes the 26S proteasome complex subunits SEM1 from Saccharomyces cerevisiae and Drosophila and DSS1 (SHFM1) in mammals. In Saccharomyces cerevisiae, SEM1 is a regulator of both exocyst function and pseudohyphal differentiation. Loss of DSS1 in Homo sapiens (human) has been associated with split hand/split foot malformations. DSS1 is playing role as a modifier in a novel protein posttranslational modification, referred to as DSSylation, which is probably targeting oxidized proteins and guiding them to proteasomal degradation.

References

References

  1. (February 1999). "SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast". Proc. Natl. Acad. Sci. U.S.A..
  2. (June 1996). "Split hand/split foot malformation, deafness, and mental retardation with a complex cytogenetic rearrangement involving 7q21.3". J. Med. Genet..
  3. (February 2014). "DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells". Protein Cell.
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