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Doxpicomine

Chemical compound

Summary

Chemical compound

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Doxpicomine (Doxpicodin, Doxpizodine) is a mild opioid analgesic drug. The drug acts as a mu-opioid receptor agonist. It is of fairly low potency, with a 400 mg dose of doxpicomine approximately equivalent in pain-killing effect to 8 mg morphine or 100 mg pethidine. It has been used as a lead compound to derive further analogues, although all compounds in this family are comparatively weak mu agonists.

References

"m-Dioxane-5-Methylamine Analgesics".
(February 1981). "Preclinical pharmacology of doxpicodin, a new analgesic". NIDA Research Monograph.
(June 1981). "Doxpicomine in postoperative pain". Clinical Pharmacology and Therapeutics.
(January 1983). "Further efficacy evaluation of doxpicomine for postoperative pain". Journal of Clinical Pharmacology.
(March 1993). "[Benzomorphan analogs with doxpicomine partial structure: synthesis andpsychopharmacologic investigations of 5-aminomethyl- and 5-(alpha-aminobenzyl)- substituted 2,6-epoxy-3-benzoxocines]". Archiv der Pharmazie.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

dimethylamino-compounds synthetic-opioids 3-pyridyl-compounds dioxanes mu-opioid-receptor-agonists

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