Dirucotide

Research

Results from a phase II and long-term follow-up trial showed that dirucotide safely delayed median time to disease progression for five years in progressive MS patients with HLA-DR2 or HLA-DR4 immune response genes. It does not seem to be effective in patients with other gene variants.

The drug is exclusively licensed by BioMS Medical Corp., a Canadian-based biotechnology company. BioMS Medical received clearance from the Food & Drug Administration (FDA) to initiate a phase III clinical trial, named MAESTRO-03, for secondary progressive MS patients in January 2007. An additional Phase III clinical trial for dirucotide, MAESTRO-01, is being undertaken in Canada and Europe. In September 2008, the drug was granted FDA fast-track for approval.

A phase II trial of Dirucotide as a potential therapy for relapsing-remitting multiple sclerosis (RRMS), MINDSET-01, failed to achieve its primary endpoint of reduced relapse rate. Nor did it reduce new MRI lesions. It did however reduce progression on the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) scale. Phase III trials are now in progress with reduction of EDSS and MSFC progression as primary endpoints.

BioMS Medical has agreed to share development of dirucotide with Eli Lilly and Company, which received exclusive worldwide rights to future research and development, manufacturing, and marketing of the compound.

Mechanism of action

T cells producing receptors recognizing MBP fragments presented by the MHC molecules of antigen presenting cells seem to play a role in the pathogenesis of MS. Repeated application of dirucotide (intravenous, every six months) represses immunological response against MBP.

Status of the development

On 27 July 2009, a statement was released, stating "BioMS Medical Corp. (TSX: MS) today announced that dirucotide did not meet the primary endpoint of delaying disease progression, as measured by the Expanded Disability Status Scale (EDSS), during the two-year MAESTRO-01 Phase III trial in patients with secondary progressive multiple sclerosis (SPMS). In addition, there were no statistically significant differences between dirucotide and placebo on the secondary endpoints of the study", this means that the MAESTRO-02 and MAESTRO-03 trials are discontinued.

References

References

1. (August 2006). "Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment". European Journal of Neurology.
2. (4 September 2008). "BioMS multiple sclerosis drug gets FDA fast track". Reuters.
3. Jeffrey, Susan. (3 February 2009). "Dirucotide Fails Primary End Point in Relapsing-Remitting MS". MedScape.
4. (17 December 2007). "Lilly and BioMS Medical Announce Global Licensing and Development Agreement". BioMS Medical Press Release.
5. (November 2008). "Molecule of the Month: Dirucotide". Prous Science.