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Dimethylethanolamine

Dimethylethanolamine (DMAE or DMEA) is an organic compound with the formula . It is bifunctional, containing both a tertiary amine and primary alcohol functional groups. It is a colorless viscous liquid. It is used in skin care products for improving skin tone and also taken orally as a nootropic. It is prepared by the ethoxylation of dimethylamine.

Industrial uses

Dimethylaminoethanol is used as a curing agent for polyurethanes and epoxy resins. It is a precursor to other chemicals, such as the nitrogen mustard 2-dimethylaminoethyl chloride. The acrylate ester, dimethylaminoethyl acrylate is used as a flocculating agent.

Related compounds are used in gas purification, e.g. removal of hydrogen sulfide from sour gas streams.

Human uses

The bitartrate salt of DMAE, i.e. N,N-dimethylethanolamine bitartrate, is sold as a dietary supplement. It is a white powder providing 37% DMAE.

Animal tests show possible benefit for improving spatial memory and working memory.

References

References

  1. (1990). "Dissociation constants of some alkanolamines at 293, 303, 318, and 333 K". Journal of Chemical and Engineering Data.
  2. {{cite encyclopedia. Matthias Frauenkron. (2002). Wiley-VCH
  3. (2011). "Ashford's Dictionary of Industrial Chemicals, 3rd edition". Wavelength.
  4. "Dimethylaminoethyl Acrylate - Global Review 2020 to 2030".
  5. (November 2002). "Dimethylethanolamine (DMAE) [108-01-0] and Selected Salts and Esters: Review of Toxicological Literature (Update) {{!}} Report on National Institute of Environmental Health Sciences Contract No. N01-ES-65402".
  6. "Sigma Aldrich: Safety Data Sheet: 2-Dimethylaminoethanol (+)-bitartrate".
  7. (2009-12-01). "Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies". Psychopharmacology.
  8. (June 1995). "Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze". Pharmacology Biochemistry and Behavior.
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