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Dimetacrine

Chemical compound

Summary

Chemical compound

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Dimetacrine (also known as dimethacrine and acripramine; brand names Istonil, Istonyl, Linostil, and Miroistonil) is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression. It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.

Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).

References

References

  1. Anvisa. (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
  2. (1996). "Dictionary of organic compounds". Chapman & Hall.
  3. (1993). "Affective Disorders: Perspective on Basic Research and Clinical Practice". Seiwa Shoten.
  4. (2007). "Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application". Wiley-VCH.
  5. (December 1966). "[Dimethacrine (istonil), an acridane derivative with the antidepressive action]". Schweizerische Medizinische Wochenschrift.
  6. (May 1968). "[Contribution to the clinical evaluation of the antidepressive effect of dimethacrine (Istonil)]". Praxis.
  7. (November 1973). "A double-blind investigation of dimethacrine versus imipramine in hospitalized depressive states". International Journal of Clinical Pharmacology, Therapy and Toxicology.
  8. (1995). "Drug actions: basic principles and therapeutic aspects". Medpharm Scientific Pub.
  9. "Dimetacrine". U.S. National Library of Medicine.
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dimethylamino-compounds tricyclic-antidepressants
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