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Dilazep

Chemical compound

Dilazep
Summary

Chemical compound

| Drugs.com = | elimination_half-life =

Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor.{{cite journal | vauthors = Deguchi H, Takeya H, Wada H, Gabazza EC, Hayashi N, Urano H, Suzuki K | title = Dilazep, an antiplatelet agent, inhibits tissue factor expression in endothelial cells and monocytes | journal = Blood | volume = 90 | issue = 6 | pages = 2345–56 | date = September 1997 | pmid = 9310485 | doi = 10.1182/blood.V90.6.2345 | doi-access = free }}

It is used for the treatment of cardiopathy and renal disorders.

Synthesis

The reaction of bis(3-hydroxypropyl)ethylene diamine (1) with 1-bromo-3-chloropropane (2) gives the homopiperazine derivative 3. Esterification by reaction with 3,4,5-trimethoxybenzoyl chloride (4) completes the synthesis of dilazep (5).

Synthesis of dilazep

References

References

  1. PubChem. "Dilazep".
  2. "Pharmaceuticals". Kowa Company Ltd..
  3. [https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-04-0094 Thieme]
  4. GB1107470 idem Herbert Arnold, Kurt Pahls, Rolf Rebling,Norbert Brock, Hans-Dieter Lenke, {{US patent. 3532685 (1970 to Asta Werke Ag Chem Fab)
  5. (1964). "Über pharmakodynamisch wirksame 3,4,5-Trimethoxybenzoate und verwandte Ester von symmetrischen Bis-hydroxyalkylpiperazinen und-dialkylpolymethylendiaminen". Monatshefte für Chemie.
Wikipedia Source

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vasodilators pyrogallol-ethers benzoate-esters diazepanes adenosine-reuptake-inhibitors
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