Surf Wiki
Save to docs
general/spiro-compounds

From Surf Wiki (app.surf) — the open knowledge base

Digitonin

4 mg/kg (mouse, intravenous)

Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant Digitalis purpurea. Its aglycone is digitogenin, a spirostan steroid. It has been investigated as a detergent, as it effectively water-solubilizes lipids. As such, it has several potential membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.

Digitonin is sometimes confused with the cardiac drugs digoxin and digitoxin; all three can be extracted from the same source.

Commercial digitonin preparations can often contain other congeners including tigonin, gitonin, digalonin, and desglucodigitonin.

Chemical properties

  • Critical micelle concentration =
  • Average micellar weight = 70000
  • Aggregation number = 60

References

References

  1. (January 1963). "Über saponine der spirostanolreihe—IX". Tetrahedron.
  2. (April 1977). "The protective action of glycyrrhizin against saponin toxicity". Biochemical Pharmacology.
  3. (February 1984). "Digitonin derivatives of low toxicity: Potential solubilizers for lipophilic compounds". Journal of Pharmaceutical Sciences.
  4. (December 2005). "The use of digitonin-permeabilized mammalian cells for measuring enzyme activities in the course of studies on lipid metabolism". Analytical Biochemistry.
  5. (April 1985). "Intracellular levels and distribution of Ca2+ in digitonin-permeabilized cells". Cell Calcium.
  6. (1986). "Separation of the components of commercial digitonin using high-performance liquid chromatography and centrifugal countercurrent chromatography. Identification of the products by californium-252 plasma desorption mass spectrometry". Biological Mass Spectrometry.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

spiro-compounds steroidal-glycosides saponins
Want to explore this topic further?

Ask Mako anything about Digitonin — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report